MF59 Adjuvant Enhances the Antibody Response to Recombinant Hepatitis B Surface Antigen Vaccine in Primates

MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates.

The effect of the proprietary adjuvant MF59 on the immunogenicity of a recombinant hepatitis B virus (HBV) vaccine, PreS2+SAg, was investigated in baboons. The magnitude and duration of the antibody response to hepatitis B surface antigen (anti-HBs) induced by the HBV/MF59 vaccine was compared with the same antigen combined with alum and with two licensed alum vaccines. After one immunization, ...

can Isolated hepatitis B core antibody in HIV-infected patients response to hepatitis B vaccine help to elucidate the cause?

significance of response to hepatitis b recombinant vaccine in subjects with isolated antibody to hepatitis b core antigen

background it is important to differentiate whether isolated anti-hbc is due to false positive results or the prior exposure to hepatitis b virus, because individuals with false-positive anti-hbc can benefit from vaccination and their blood can be safely transfused. to distinguish between these two conditions, we evaluated the serologic response to hepatitis b vaccine. methods ninety subjects w...

Significance of Response to Hepatitis B Recombinant Vaccine in Subjects with Isolated Antibody to Hepatitis B Core Antigen

BACKGROUND It is important to differentiate whether isolated anti-HBc is due to false positive results or the prior exposure to hepatitis B virus, because individuals with false-positive anti-HBc can benefit from vaccination and their blood can be safely transfused. To distinguish between these two conditions, we evaluated the serologic response to hepatitis B vaccine. METHODS Ninety subjects w...

Vaccine adjuvant ginsenoside Rg1 enhances immune responses against hepatitis B surface antigen in mice.

The adjuvant effect of ginsenoside Rg1 on immune responses against hepatitis B surface antigen (HBsAg) in mice was investigated. Female BALB/c mice were subcutaneously injected with saline or HBsAg antigen with or without Rg1 on days 7 and 21. Samples were collected 2 weeks after the boosting for the detection of anti-HBsAg immunoglobulin G (IgG) isotypes in sera and gamma interferon (IFN-γ) an...